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Conclusion: These results could contribute to the validation of the medical use of these extracts that exert an antiplatelet effect to treat hemostatic and thrombotic disorders. Keywords: Medicinal plants of Morocco, aqueous extract, antiplatelet aggregation, antioxidant activity, phytochemical analysis, secondary metabolites.
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Nine essential oils, hydrodistilled from different parts of five Goniothalamus species (G. velutinus Airy-Shaw, G. woodii Merr., G. clemensii Ban, G. tapis Miq. and G. tapisoides Mat Salleh) were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on …
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This is the first experimental study to demonstrate the potent dose-dependent antiplatelet aggregation, anticoagulant and antioxidant activity of C. edulis rhizome and …
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The antiplatelet activity of numerous fruits and vegetables and their multiple mechanisms of action have recently been highlighted. ... Several dietary supplements and plant or fruit extracts have been reported to exert beneficial and protective effects ... and Lupin (Lupinus spp.) extracts on human platelet aggregation. Plant Foods Hum. Nutr ...
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Then, exploration of medicinal plants which have cardioprotective activity especially as antiplatelet aggregation agent are needed. One of the medicinal plant, Centella asiatica (L.) Urban, has ...
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Plants of the Dendrobium genus, one of the largest in the Orchidaceae, manifest a diversity of medicinal effects encompassing antiangiogenic, immunomodulating, antidiabetic, cataractogenesis-inhibiting, neuroprotective, hepatoprotective, anti-inflammatory, antiplatelet aggregation, antifungal, antibacterial, antiherpetic, …
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This review, covering the literature from 1966 to the present (2020), describes naturally occurring fungal bioactive anthraquinones and analogues biosynthesized by the acetate route and concerning several different functionalized carbon skeletons. Hydrocarbons, lipids, sterols, esters, fatty acids, derivatives of amino acids, and aromatic compounds …
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Antiplatelet aggregation and anticoagulant action of processed products with vinegar is the most powerful. [Studies on antiplatelet aggregation and anticoagulant action of Curcuma phaeocaulis] Zhong Yao Cai. 2000 Apr;23(4):212-3. ... Plants, Medicinal / …
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This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders. Natural Products with Antiplatelet Action ... components, which are directly related to the antiplatelet activity of the plant, such as ...
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Antiplatelet aggregation constituents from Annona purpurea J Nat Prod. 1998 Dec;61(12):1457-61. doi: 10.1021/np9800046. Authors F R Chang 1 ... Plants, Medicinal / chemistry* Platelet Aggregation Inhibitors / isolation & purification* Platelet Aggregation Inhibitors / pharmacology ...
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Plants primarily use alkaloids to protect themselves from herbivores and diseases. Alkaloids are used in ancient and modern medicines in amounts ranging from 25 to 75%, demonstrating their ...
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Six diterpene alkaloids with an atisine-type C(20)-skeleton isolated from the Chinese herbal medicines Spiraea japonica var. acuta and S. japonica var. ovalifolia, as well as eight derivatives of spiramine C and spiradine F were evaluated for the ability to inhibit aggregation of rabbit platelets induced by arachidonic acid, ADP, and platelet …
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In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. ... (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically ...
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Antiplatelet aggregation: Lonicera japonica Thunb. Antiplatelet aggregation: Lycopus lucidus Turcz. Inhibit aggregation of red blood cells: Liriope …
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From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, …
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Objective: The antiplatelet aggregation compounds in Rhizoma Corydalis were screened to validate its traditional medicinal use. Material and methods: Total alkaloid extract (TAE) of Rhizoma Corydalis was obtained by refluxing 100 g Rhizoma Corydalis powder with 600 mL 70% ethanol, and purified by acidification (20% HCl) and alkalization (5 M ...
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WEBAcquired data showed that A. atroviolaceum exerted a maximum antiplatelet aggregation effect compared to other allium species . Moreover, the …
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The ethyl acetate extract of an endophyte Epicoccum sorghinum exhibited anti-inflammatory activity at a concentration of <10 μg/mL. By bioassay-guided fractionation, one new compound, named epicorepoxydon A (1), and one unusual bioactive compound, 6-(hydroxymethyl)benzene-1,2,4-l (6), together with six known compounds, were …
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Several of these isolated compounds exhibited significant antiplatelet inhibition against arachidonic acid-induced aggregation, collagen-induced, and PAF-induced aggregation (Chen et al., 2001). Altogether, these findings showed the potential of plant alkaloids as antiplatelet agents or lead compounds.
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Coumarins and antiplatelet aggregation constituents from Formosan Peucedanum japonicum Phytochemistry. 1996 Feb;41(2):525-30. doi: 10.1016/0031-9422(95)00625-7. ... Plant Extracts / chemistry* Plants, Medicinal / chemistry* Platelet Aggregation Inhibitors / …
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Conclusions. This is the first experimental study to demonstrate the potent dose-dependent antiplatelet aggregation, anticoagulant and antioxidant activity of C. edulis rhizome and its pure compounds, supporting the traditional use of this plant for the treatment of heart diseases. The C. edulis rhizome is a potential source of bioactive …
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The latter showed the strongest antiplatelet activity with an IC 50 of 70.4 μM against AA-induced platelet aggregation. Seventeen aporphines were tested for antiplatelet activity. L- (+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic …
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In traditional medicine, plants are used either whole or as parts (Khan, 2014). Literature reveals the antiplatelet activity of common edible plant products as apples, strawberry, tomatoes, spinach, among others (Bondonno et al., 2012, Alvarez-Suarez et al., 2014, Alarcòn et al., 2014, Fuentes et al., 2013).
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Adenosine-5′-diphosphate (ADP) plays a crucial role in platelet activation [1, 2].In addition, platelet hyperactivity is known to be associated with vascular disease and has a key role in haemostasis and thrombosis [3, 4].ADP is considered a weak platelet agonist, since it induces platelet shape change (PSC, an early phase of platelet activation) and …
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Antiplatelet medications divide into oral and parenteral agents, and oral agents subdivide further based on the mechanism of action. Aspirin was the first antiplatelet medication and is a cyclooxygenase inhibitor. ... while PGI2 works by inhibiting platelet aggregation and induces vasodilation, and is mediated by COX-2. Low-dose …
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Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation.
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It is the first report that C 20 -diterpene alkaloids inhibit PAF-induced platelet aggregation. However, spiramine C1 concentration-dependently inhibited platelet aggregation induced by PAF, ADP and arachidonic acid with IC 50 values of 30.5±2.7, 56.8±8.4 and 29.9±9.9 μM, respectively, suggesting a non-selective antiplatelet …
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In the antiplatelet aggregation assay, phenanthrenes 1 and 2 showed potential antiplatelet activity. We have reported and discussed here the antiplatelet aggregation properties of the eleven naturally-occurring phenanthrenes (1-2 and 9-17) isolated from the underground part of the plant and eighteen chemically synthesized phenanthrenes (18-35).
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This systemic review mainly is focused on herbal plants as antiplatelet in various traditional medicines and explores the herbal plant, isolated active constituent and formulation with antiplatelet activity. ... Phytochemistry, 67(8), 2006, 824-29. Chang FR, Wei JL, Teng CM, and Wu YC, Antiplatelet aggregation constituents from Annona …
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The Alkaloid biosynthesis pathway is specifically involved in the decarboxylation of compounds (Grynkiewicz and Gadzikowska, 2008 ). Medicinal plants are a rich source of alkaloids having antiplatelet and anticoagulant activities. The commonly used antiplatelet, aspirin, originated from salicin obtained from willow plant …
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